Fluconazole
Generic: Diflucan
Indication: Candidiasis (oropharyngeal, esophageal, vaginal, systemic); Cryptococcal meningitis
Pediatric dosage: Oropharyngeal candidiasis: 6 mg/kg PO/IV on day 1, then 3 mg/kg once daily for 7-14 days. Esophageal candidiasis: 6 mg/kg PO/IV on day 1, then 3-6 mg/kg once daily (max 200 mg/day) for 14-21 days. Systemic candidiasis: 6-12 mg/kg/day PO/IV once daily. Cryptococcal meningitis: 12 mg/kg PO/IV on day 1, then 6-12 mg/kg once daily (max 800 mg/day). Neonates (monitor serum concentrations): <1 kg, ≤14 days old: 6 mg/kg/dose every 72 hours <1 kg, 15-28 days old: 6 mg/kg/dose every 48 hours 1-2 kg, ≤7 days old: 6 mg/kg/dose every 48 hours 1-2 kg, 8-28 days old: 6 mg/kg/dose every 24 hours >2 kg: 6 mg/kg/dose every 24 hours
Route: Oral, IV
Frequency: Once daily (varies by indication and age)
Warnings: QT prolongation risk; hepatotoxicity possible. Monitor LFTs in prolonged therapy. Adjust dose in renal impairment.